Platelet Serotonergic Markers as Endophenotypes for Obsessive-Compulsive Disorder
نویسندگان
چکیده
منابع مشابه
Neurocognitive endophenotypes of obsessive-compulsive disorder.
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized to represent genetic risk for polygenic disorders at more biologically tractable levels than distal behavioural and clinical phenotypes. It is theorized that endophenotype models of disease will help to clarify both diagnostic classification and aetiological understanding of complex brain disorde...
متن کاملEndophenotypes and serotonergic polymorphisms associated with treatment response in obsessive-compulsive disorder
OBJECTIVES Approximately 40-60% of obsessive-compulsive disorder patients are nonresponsive to serotonin reuptake inhibitors. Genetic markers associated with treatment response remain largely unknown. We aimed (1) to investigate a possible association of serotonergic polymorphisms in obsessive-compulsive disorder patients and therapeutic response to selective serotonin reuptake inhibitors and (...
متن کاملAssociation study between obsessive-compulsive disorder and serotonergic candidate genes.
BACKGROUND To date, research examining the relationship between serotonergic genes and obsessive-compulsive disorder (OCD) has yielded conflicting results. The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD. METHODS 99 OCD patients, 4...
متن کاملAtomoxetine Induced Obsessive-Compulsive Disorder
Introduction: Attention deficit and hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Atomoxetine is a non-stimulant drug used in the treatment of ADHD. Case Presentation: In this article, a case of obsessive-compulsive disorder (OCD) which occurred in an 11-year-old boy with an increased dose of atomoxetin...
متن کاملPharmacotherapy for obsessive–compulsive disorder
Considered untreatable before the 1960s, obsessive–compulsive disorder (OCD) remains a common and enduring illness that can affect any age group (Skoog 1999). Pharmacotherapy for the disorder began in the 1960s, which saw the introduction of the tricyclic agent clomipramine. Treatment has since evolved, with selective serotonin reuptake inhibitors (SSRIs) in the 1980s and augmentation with anti...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2005
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300752